• Organ fibrosis is thought to be initiated by repeated or

  2020-01-14

  

  Organ fibrosis is thought to be initiated by repeated or chronic epithelial injury. The current belief is that damaged epithelial Irinotecan induce an aberrant and unresolved wound repair process by activating fibroblasts via various profibrotic cues. Upon injury, epithelial cells activate the prof

• Other enzymes outside of the circadian clock also

  2020-01-14

  

  Other galeterone synthesis outside of the circadian clock also have effects on CR. Lithium, a drug used to treat bipolar disorder, has been shown to lengthen τ in a variety of systems [17]. While the molecular mechanism whereby lithium exerts its therapeutic effect is unclear, it is known to be an i

• There is a large interindividual difference in intestinal ch

  2020-01-14

  

  There is a large interindividual difference in intestinal cholesterol K02288 of cholesterol that is mainly due to genetic variation [15], [19]. Single nucleotide variation (SNV) in NPC1L1 and, ABCG5 and ABCG8 key modulators of cholesterol influx and efflux into intestinal mucosal cells, respectivel

• Previously we have described increased expression of both cy

  2020-01-14

  

  Previously, we have described increased expression of both cytokine and chemokine mRNA (e.g. MCP-5 and fractalkine) in the left ventricle of male EP4-KO mice with dilated cardiomyopathy [2]. Takayama et al. [31] have shown that PGE2 potently inhibits cytokine/chemokine secretion (MCP-1, interleukin

• The glycolytic pathway is a catabolic route that ends with

  2020-01-14

  

  The glycolytic pathway is a catabolic route that ends with the synthesis of pyruvate (Pyr). In Arabidopsis embryos, the conversion of phosphoenolpyruvate (PEP) to Pyr, catalyzed by pyruvate kinase (PK), is mainly located in the plastids [10], [11]. The preceding reaction is catalyzed by enolase (ENO

• br E mediated E discharge E ligases simultaneously interact

  2020-01-14

  

  E3-mediated E2 discharge E3 ligases simultaneously interact with the substrate and the SUMOD charged E2 enzyme to catalyze the discharge of the thioester-bound SUMOD from the E2 to the substrate. E3 interaction with SUMOD via a SIM results in a closed conformation which is highly reactive and lea

• Increasing evidence suggests that normal vaginal

  2020-01-13

  

  Increasing evidence suggests that normal vaginal delivery is a natural inflammatory process which results in increased levels of cytokines like Interleukin-6 (IL-6), Interleukin-8 (IL-8) in maternal and cord blood plasma [10]. Increased levels IL-6 and IL-8 have been reported in the amniotic fluid o

• Cytochrome P CYP enzymes plays

  2020-01-13

  

  Cytochrome P450 (CYP-450) enzymes plays an essential role in pharmacology of drugs and toxicology of xenobiotics. Inhibition of these enzymes may lead to increase plasma levels of a concomitantly administered drug (Lee et al., 2013). It may prolong or reduce the pharmacological effects and increase

• br Conclusion Blueberry is becoming a worldwide crop

  2020-01-13

  

  Conclusion Blueberry is becoming a worldwide crop with the fastest rising consumer demand trends for its health benefits. However, the berry size is one of the key parameters for determining fruit quality and consumers’ preferences (Milic et al., 2018). Understanding the physiological and molecul

• DDX belongs to the DEAD box family of

  2020-01-13

  

  DDX3 belongs to the DEAD-box family of proteins, ATP-dependent RNA helicases characterized by the presence of a highly conserved helicase core domain [13]. This catalytic core is composed of two RecA-like domains containing motifs involved in ATP binding/hydrolysis, RNA binding and helicase activity

• This paper proposes an acceptance process

  2020-01-13

  

  This paper proposes an acceptance process and evaluation criteria, specialized for the dedication of indirect COTS SW as well as direct ones. (Step 1) It first recognizes an indirect COTS SW as a target of dedication, unlike EPRI NP-5652/TR-106439. (Step 2) It then determines the safety category of

• br Materials and methods br Results br Discussion For

  2020-01-13

  

  Materials and methods Results Discussion For many years, oral PDE5-Is have been prescribed as an on-demand regimen for treating ED. Several studies have reported on the efficacy and safety of such a regimen, with an overall efficacy rate of 60–70% [21]. However, many patients complain of a

• EphB promotes tumor growth by stimulating angiogenesis throu

  2020-01-13

  

  EphB4 promotes tumor growth by stimulating angiogenesis through EphrinB2 [18]. However, the distinct and specifically involvement of 57 9 sale and veins in the tumor angiogenesis of all tumor grades is unclear. Our results indicate that the relation between EphrinB2 and EphB4 stained blood vessels w

• br Activatable MRI probes MRI is commonly used

  2020-01-13

  

  Activatable MRI probes MRI is commonly used in clinics around the world and has the advantages of outstanding tissue-penetration depth and extremely high spatial resolution for in vivo imaging [33]. MRI has relatively poor sensitivity and usually requires K02288 agents to enhance the imaging con

• Gene expression profiling with corresponding clinical data s

  2020-01-13

  

  Gene dextromethorphan hydrobromide profiling with corresponding clinical data supported the notion that increased expression of S1PR1 in DLBCL was associated with poor outcome [159], [160], [161]. These studies also identified increased expression of the GPCRs GPR183, CCR7, ADRB2 and CNR2 as risk fa

16044 records 922/1070 page Previous Next First page 上5页 921922923924925 下5页 Last page