• br Acknowledgements br Introduction Autism is a neurodevelop

  2020-08-06

  

  Acknowledgements Introduction Autism is a neurodevelopmental disorder, and in which its main diagnostic symptoms are unfamiliar common social interactions, with intense deficiencies in social cognition in several cases (Chevallier et al., 2012, Constantino, 2011). Improper understanding of soc

• According to Graeff Graeff innate fear is mediated by

  2020-08-06

  

  According to Graeff (Graeff, 1990), innate fear is mediated by neural circuitry that consists of at least the amygdala, medial hypothalamus and periaqueductal grey matter. In particular, the BLA has been considered to be a structure closely related to emotional responses to fear, stress and anxiety

• Based on the finding described above the present

  2020-08-06

  

  Based on the finding described above, the present study was designed to investigate the effects of specific CRF receptors, CRF1 and CRF2, in the BLA and CeA on the duration of TI in guinea pigs (Cavia porcellus). To this end, we evaluated whether administration of the CRF1 bml definition antagonist

• Although retention effects might stem from differences in bo

  2020-08-06

  

  Although retention effects might stem from differences in both consolidation and/or recall of extinction memory, prefrontal dopamine – and thereby COMT enzyme bosentan – might be particularly relevant for consolidation as indicated by studies on endogenous prefrontal dopamine release in rats after

• Over the last years it has become

  2020-08-05

  

  Over the last 5 years, it has become clear that proper regulation of apoptosis is dependent on appropriate ubiquitylation of various cellular components (Vucic, Dixit, & Wertz, 2011). Here, we have focused on IAP proteins that contain a RING domain, but other E3 ligases such as MDM2, which is the pr

• 1,2-Dilauroyl-sn-glycerol Like other Ub Ubl modifiers the pr

  2020-08-05

  

  Like other Ub/Ubl modifiers, the process of protein UFMylation is controlled by an E1–E2–E3 enzymatic cascade (). First, the UFM1 activating E1 enzyme (UBA5) catalyzes the ATP-dependent adenylation of the UFM1 C-terminal carboxylate., The subsequent intermolecular nucleophilic attack of the UFM1-ad

• br Introduction Cancer is the second cause of death and

  2020-08-05

  

  Introduction Cancer is the second cause of death and responsible for one-sixth of the deaths (estimated 9.6 million) all over the world in 2018 [1]. And the International Agency for Research on Cancer (IARC) estimated that there would be 21.7 million new cancer cases and 13 million cancer deaths

• Funding sources This study was funded by European

  2020-08-05

  

  Funding sources This study was funded by European Community’s Seventh Framework Programme under grant agreement No. 305662 (Project: Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health: a cluster-randomized trial ‘COSMIC’). Acknowledg

• We used the conditions for covalent

  2020-08-05

  

  We used the conditions for covalent linkage of photoreactive THPs that were previously optimised for the integrin-binding THP, GFOGER [15], where, after 5 min of UV treatment and at a THP concentration of 5 μg/ml, maximal and specific covalent linkage of the photoreactive THP was observed. We antici

• Some limitations to our study

  2020-08-05

  

  Some limitations to our study should be noted. First, the sample size of our study was limited. As DDR2 mutations are rare in lung SCC, it is possible that the power of our study was insufficient to detect potential associated factors. Second, a significant proportion of the 271 sequenced patients h

• In the presence of l serine borate the CysLT receptor

  2020-08-05

  

  In the presence of l-serine borate, the CysLT1 receptor antagonist montelukast did not inhibit and only partially inhibited the LTC4-induced contractile responses in the fundus and antrum, respectively. This is in agreement with a previous study showing a difference in the antagonist sensitivity bet

• It has previously been shown that human melanocytes are resp

  2020-08-05

  

  It has previously been shown that human melanocytes are responsive to a multiplicity of hormonal triggers [10], particularly to pituitary or ovarian hormones [11]. Studies concerning the effects of SRT2104 sale on human melanocytes led to inconsistent data [12], [13]. Im et al. [14] reported that t

• br Acknowledgment This work is supported by the German

  2020-08-04

  

  Acknowledgment This work is supported by the German Research Foundation (DFG) grant RA2717/2–1 (AYR and NF). The ubiquitin proteasome system The ubiquitin proteasome system (UPS) plays a significant role in the regulation of cell growth and survival, in addition to maintaining cellular homeos

• br Conflicts of interest br Introduction Ubiquitin

  2020-08-04

  

  Conflicts of interest Introduction Ubiquitin-mediated signal transduction depends on a balance between tightly regulated ubiquitin ligase and deubiquitinating enzyme (DUB) activities (Komander and Rape, 2012, Komander et al., 2009). Additional layers of control occur at the level of ubiquitin

• HvPap a member of the

  2020-08-04

  

  HvPap-1, a member of the cathepsin F-like family, was identified in germinating barley seeds (Sreenivasulu et al., 2008). This enzyme participates in the mobilization of stored proteins (mainly hordeins) during the last phase of grain germination, and its activity is modulated by a propeptide or/and

16045 records 824/1070 page Previous Next First page 上5页 821822823824825 下5页 Last page