• Tibolone is also efficacious on bone in

  2021-07-02

  

  Tibolone is also efficacious on bone in elderly women and induces a clear reduction in bone turnover markers [50], [51]. Rymer et al. showed that, after 10 years of treatment with tibolone, the difference in bone mineral density compared with a placebo group was more than 12% for both lumbar spine a

• br Materials and methods br Results br Discussion Our previo

  2021-07-02

  

  Materials and methods Results Discussion Our previous study showed that ERRγ negatively regulates osteoblast differentiation via inhibiting Runx2 transactivity (Jeong et al., 2009). In the present study, we found that ERRγ also induced miR-433 in osteogenic mesenchymal cell lineage C3H10T1/

• br Materials and methods br Results br

  2021-07-02

  

  Materials and methods Results Discussion Inflammatory signalling and in particular the arachidonic Terfenadine cascade have been suggested as targets for disease modification, optimization of the therapeutic response, and even restoration of pharmacosensitivity (Potschka, 2010). Recently,

• br Halogenases Enzymatic C H

  2021-07-02

  

  Halogenases Enzymatic C–H activation leading to halogenation is another emerging area in biocatalysis [55,56]. Incorporation of halogen atoms during medicinal chemistry eff ;orts is a well-established practice, presenting an effective means to control the molecule’s bioactivity and physicochemical

• br Materials and methods F philippinensis plants were collec

  2021-07-02

  

  Materials and methods F. philippinensis plants were collected in August 2014 at a farm in Ninning, Guangxi province, China and identified by Dr. Yimmin Zhao. Voucher specimens (No. 530) were deposited in the Herbarium of Gaunxi Botanical Garden, China. Human recombinant neutrophil elastase (EC 3.

• Carbazole could be recrystallised from

  2021-06-29

  

  Carbazole could be recrystallised from ethyl acetate to provide bright red crystals suitable for single crystal X-ray diffraction (see ). The first crop showed had crystallised preferentially as the ()-isomer (A). Examining the single crystal X-ray data of it was interesting to find that the N2C1

• Given the excellent in vitro pharmacology

  2021-06-29

  

  Given the excellent in vitro pharmacology profiles of methyl ester 28 and primary amide 29 efforts were reengaged on neutral analogs of these leads, with a focus on non-amide replacements for the carboxylic isoxsuprine functionality of 1. Acetonitrile 49 was found to have a good balance of DGAT-1 in

• The sex dimorphic expression of mouse CYP A

  2021-06-29

  

  The sex-dimorphic Iohexol sale of mouse CYP3A is partially due to sex-dimorphic plasma GH profile which is a decisive factor in the regulation of sexspecific CYP isoforms [14]. Nevertheless, in our study we did not observe any changes in plasma GH levels in either mouse sex with a selective ablatio

• br Results and discussion br Conclusion This study describes

  2021-06-29

  

  Results and discussion Conclusion This study describes the development of a highly sensitive on-sorbent derivatisation technique, using the novel high-surface area CMV devices, to sample methamphetamine vapour. Previous methods for air sampling for methamphetamine such as sampling cassettes ha

• Two nutrient sensing pathways the cAMP

  2021-06-28

  

  Two nutrient-sensing pathways, the cAMP-protein kinase A (PKA) pathway and the target of rapamycin complex 1 (TORC1) pathway, are implicated in Msn2/4 regulation. Under non-stress conditions, Msn2 localizes in the cytoplasm and is inactivated by both PKA-dependent phosphorylation of the nuclear loca

• As for the molecular mechanism Ferguson BD

  2021-06-28

  

  As for the molecular mechanism, Ferguson BD suggested that EphB4/EphrinB2 stimulation induced topoisomerase I activity in small cell lung cancer cell lines. Treatment of PP121 receptor with EphrinB2/Fc induced topoisomerase activity as assessed by DNA relaxation in cells with high EphB4 expression

• Introduction Neuropathic pain occurs in

  2021-06-28

  

  Introduction Neuropathic pain occurs in approximately one-third of patients with diabetes and is refractory to currently available analgesic drugs (Abbott et al., 2011). This painful diabetic neuropathy (PDN) is associated with elevated levels of methylglyoxal (MG; a reactive glucose metabolite) an

• br Experimental Procedures br Author Contributions br

  2021-06-28

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Breast cancer is one of the most common malignancies for women worldwide, representing approximately 22% of women’s malignancies that pose a threat to women’s health [[1], [2], [3], [4]]. The morbidity rate of brea

• PBMC derived macrophages not only express

  2021-06-28

  

  PBMC-derived macrophages not only express EBI2 but also have the ability to respond to their natural agonist 7α,25-OHC by activating downstream signal transduction pathways. In line with previous findings, our data confirm that receptor stimulation induces calcium mobilization which can be blocked b

• One of the hallmarks of the terminal stages

  2021-06-28

  

  One of the hallmarks of the terminal stages of apoptosis is the fragmentation of chromosomal DNA that proceeds in a two-step manner: the DNA is initially cleaved into 50–300kb fragments and eventually into oligonucleosomal pieces [12], [13]. The two major apoptotic nucleases are DNA fragmentation fa

16048 records 649/1070 page Previous Next First page 上5页 646647648649650 下5页 Last page