• p neurotrophin receptor p NTR

  2021-11-03

  

  p75 neurotrophin receptor (p75NTR or CD271), a member of the tumor necrosis factor receptor superfamily, has been implicated in several steps of glioma tumorgenesis [5]. p75NTR mediates glioma invasion and progression through γ-secretase-dependent and -independent mechanisms [6], [7], and its expres

• br Materials and methods br Results To examine

  2021-11-03

  

  Materials and methods Results To examine the time and organ specific effect of normal photoperiod and dark environment on the l-ascorbic acid of different SlHXKs and on the enzyme activities, these parameters were determined in different leaf positions of tomato plants. Under control condition

• An interesting question is why RhoF has

  2021-11-03

  

  An interesting question is why RhoF has such the slow rate of GDP dissociation. The amino AMG-208 mg mutations in a presumable GDP-binding site of RhoF had only moderate effects on the GDP dissociation (Fig. 3C), which suggests a mechanism involving the global amino acid sequence of RhoF, rather th

• BX-912 We also investigated fat depots in mesenteric and ret

  2021-11-03

  

  We also investigated fat depots in mesenteric and retroperitoneal adipose tissues as well as in the liver and verified a reduction in lipid droplets following exercise or exercise and FS oil treatments in the liver from obese mice. Potential molecular candidates in the modulation of adipose tissue b

• br Materials and methods br Results br Discussion l glutamat

  2021-11-03

  

  Materials and methods Results Discussion l-glutamate is the major excitatory neurotransmitter in the brain, and is functionally involved in many processes of the nervous system which have been connected with several neurological diseases [4]. These conditions are characterized by the time-d

• Recent studies suggested that non coding

  2021-11-03

  

  Recent studies suggested that non-coding RNAs participate in the modulation of Glut1 expression. For instance, the lncRNA NBR2-Glut1 axis was suggested to modulate cancer cell sensitivity to phenformin [37]. In renal carcinoma, miR-1291 is involved in the regulation of Glut1 CC-115 [38]. Therefore,

• Our data suggest that Slc a is important for

  2021-11-03

  

  Our data suggest that Slc38a5 is important for amino-acid-induced α cell proliferation and expansion of α cell mass following GCGR inhibition, but not for formation and maintenance of α cell mass. This is supported by the finding that Slc38a5−/− mice have normal α cell mass. This is interesting sinc

• The widespread involvement of HH GLI in human malignancies h

  2021-11-03

  

  The widespread involvement of HH/GLI in human malignancies has initiated a remarkable effort to identify selective HPIs. As shown in Table 2.1, most of these small molecule inhibitors target the essential effector protein SMO, which should lead to pathway abrogation by eventually decreasing the GLIA

• The effect of exercise on plasma

  2021-11-03

  

  The effect of exercise on plasma ghrelin has previously been investigated mostly in humans using exercise regimens such as treadmill running, cycling, and rowing, and also in a few rodent studies and in some other animal models. While many of these clinical studies and some preclinical studies demon

• The first GSM was identified from the

  2021-11-03

  

  The first GSM was identified from the discovery of non-steroidal anti-inflammatory drugs (NSAIDs). An amyloid reducing GSM that also suppresses inflammation is desirable. Inflammatory response is an invariable characteristic of AD pathogenesis, in part triggered by Aβ. During AD onset and progressio

• Similarly spectrophotometric titrations were carried

  2021-11-03

  

  Similarly, spectrophotometric titrations were carried out under conditions identical to those used for the fluorescence titrations. exhibited a predominant Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO) band at around 493 nm. The titrations with all G-quadruplex DNAs resulted in a hypochrom

• br Acknowledgments We apologize for the omission of primary

  2021-11-03

  

  Acknowledgments We apologize for the omission of primary citations owing to space limitations. This work was supported by grants from National Natural Science Foundation of China (81772801 and 81472455 to C.D.), the Key Program of Zhejiang Provincial Natural Science Foundation (LZ17H160002 to C.D

• br Introduction Before planning population

  2021-11-03

  

  Introduction Before planning population-based genetic analysis or GWAS, it is important to annotate the sequence of the gene because these sequences represent the major sites such as promoter and transcription factor 2111 which may ultimately affect the expression of the gene. Similarly, a singl

• H O induced astrocyte ATP

  2021-11-03

  

  H2O2 induced astrocyte ATP release through lysosome exocytosis. The LDH assay and electric microscope results indicated that the increase of extracellular ATP concentration was not due to the cell rupture, but the alternations in cell activities. In addition, when lysosome exocytosis was blocked by

• br Materials and methods br Results

  2021-11-02

  

  Materials and methods Results Estimations of OMP generated by the proposed mechanism (Fig. 1) were first performed for the range of 0.001–2 mM of Tempol mg concentration in the cytosol. It was assumed that only 5% of all VDACs in MOM form the ANT-VDAC1-HKI contact sites, and that the fraction

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