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br Materials and met http www apexbt com media diy
2024-04-29

Materials and methods Results The values for body weight are shown in Fig. 1. Body weight was measured every day. The body weight of the young mice in the control (i.e. no-stress) group was not significantly different from that of the young mice in the stress group. However, the middle-aged mi
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The number of times an animal reared was the only
2024-04-29

The number of times an animal reared was the only emotional behavior that was significantly higher in the young mice than in the middle-aged group. This may be explained by diminished curiosity or augmented ambulation with aging (Lalonde and Strazielle, 2008). A recent study showed that middle-aged
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Nx rats feces collected in nd week
2024-04-29

5/6Nx rats’ feces collected in 2 nd week, 4 th week, 6 th week, 8 th week and 10 th week were tested by 16S rDNA sequencing. The 16S rDNA sequencing data was analyzed in the level of PHYLUM, CLASS, ORDER, FAMILY and GENUS. There are more than 1000 types of gut microbiota in the level of Genus [50],
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In terms of the full
2024-04-29

In terms of the full-length proteins, it was noted early on that ACs have two cellular localizations: as integral proteins of the plasma membrane and as soluble proteins in the cytosol. Based on the distribution in mammalian sequences, it was initially proposed that subclass IIIa contains only membr
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Bioactive peptides contain amino acids with
2024-04-29

Bioactive peptides contain 2–20 amino acids with possible bioactivities including antihypertensive, antioxidant, antimicrobial, anticancer, and opioid activity [9], [10], [11]. There has been a great interest in antihypertensive peptides for their efficiency in lowering blood pressure. The antihyper
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br Acknowledgments br Introduction Hypospadias is a common c
2024-04-29

Acknowledgments Introduction Hypospadias is a common congenital malformation in males, in which the urethral orifice is found on the ventral side of the penis as a result of incomplete fusion of urethral folds. The mean prevalence in per 10,000 live births from 1910 to 2013 were: Europe 19.9,
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Axl has been reported to mediate cell
2024-04-29

Axl has been reported to mediate cell-cell adhesion and sphere-growth [11], [18] and to be important for metastasis to secondary organs [12], [14], [20]. We found an Axl-dependent CCRCC-ability of sphere-formation and repopulation after non-adhesive growth. Axl-inhibited cells could not attach to ea
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br Funding br Ethics br Conflict of interest br
2024-04-29

Funding Ethics Conflict of interest Acknowledgements Introduction Hepatic fibrosis occurs in response to different etiologies of chronic liver injury, which is mainly accompanied by pathological LY3009104 synthesis of excessive extracellular matrix (ECM) of the liver, as the common re
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br Disclosure statement br Acknowledgements The
2024-04-29

Disclosure statement Acknowledgements The work was supported by the National Science Foundation of China (Nos. 81273526, 81473268) and Natural Science Foundation of Colleges and Universities (Nos. KJ2017A197). What is already known What this article adds Introduction Sevoflurane is o
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The analysis of the profile of protein phosphorylation
2024-04-29

The analysis of the profile of protein phosphorylation in MMS-treated TRAM 39 confirmed that both the ATM and ATR pathways were activated in S-phase blocked cells. Interestingly, phosphorylation of Chk1 was observed 24h after MMS-treatment both in AT- and ATM-inhibited cells, whilst in the absence
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Similar studies in Swedish Mutation of APP AD
2024-04-28

Similar studies in Swedish Mutation of APP AD transgenic mice revealed reduced dynamin 1, AP180, and synaptophysin expression in the hippocampus, particularly prominent in the CA1 and CA4 subfields [19]. These findings imply that Aβ can act not only as a modulator of exocytosis but is a potent regul
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br Neurological development and BCAAs Glutamate is an
2024-04-28

Neurological development and BCAAs Glutamate is an important excitatory neurotransmitter in the brain, and BCAAs (especially leucine) function to synthesize glutamate in astrocytes around neurons, since leucine enters the brain from the blood more rapidly than other pyruvate dehydrogenase kinase
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At the organismal level skeletal muscle
2024-04-28

At the organismal level, skeletal muscle, lung and adipose tissues mediate net de novo synthesis and release of glutamine, whereas net glutamine catabolism occurs in the kidney [7]. The liver exhibits net glutamine consumption coupled to urea production in the post-absorptive state, and net glutamin
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Since the first studies of betaine aldehyde oxidation
2024-04-28

Since the first studies of betaine aldehyde oxidation in rats [13], the participation of betaine in the detoxification of homocysteine has well described, considering the activity of other hiv protease inhibitor as betaine homocysteine methyltransferase and methionine synthase. But, there is a lack
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In the search for more specific inhibitors of uptake Iversen
2024-04-28

In the search for more specific inhibitors of uptake2, Iversen and Salt (1970) speculated that steroids may potentiate the actions of catecholamines on vascular smooth muscle by inhibiting uptake2-mediated catecholamine clearance of the transmitters. They went on to demonstrate that a variety of ste
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